GALAXYÑо¿ÊÇÒ»ÏîǰհÐԵĴó¹æÄ£Ñо¿£¬Ö¼ÔÚ¼à²âIIÆÚÖÁIVÆÚ¿ÉÇгý½áÖ±³¦°©£¨CRC£©»¼ÕßµÄÑ»·Ö×ÁöDNA£¨ctDNA£©¡£ÕâÏîÑо¿ÊÇCIRCULATE-JapanÏîÄ¿µÄÒ»²¿·Ö£¬¸ÃÏîÄ¿»¹°üÀ¨Á½ÏîIIIÆÚËæ»úÑо¿£ºVEGAºÍALTAIR¡£GALAXYÑо¿Ê¹ÓøöÐÔ»¯µÄÖ×ÁöÒÑÖªctDNA¼ì²â¾ÙÐÐÒ»Á¬ctDNAÆÊÎö£¬ÆðÔ´ÆÀ¹ÀÔÚÊõºó4ÖܾÙÐУ¬×÷ΪÆÀ¹À·Ö×Ó²ÐÁô²¡£¨MRD£©µÄÆðʼµã¡£ËæºóµÄÆÀ¹ÀÔÚÊÖÊõºó3¡¢6¡¢9¡¢12¡¢18ºÍ24¸öÔ»òÖ±ÖÁ¸´·¢¾ÙÐС£
ÏÖÔÚ£¬Ñ»·Ö×ÁöDNA£¨ctDNA£©ÒѳÉΪ¼ì²â·Ö×Ó²ÐÁô¼²²¡£¨MRD£©ºÍÕ¹Íû¸´·¢µÄÒ»ÖÖ΢´´ÉúÎï±ê¼ÇÎï¡£µ«»ùÓÚÉúÎï±ê¼ÇÎïµÄÖÎÁÆÔÚ¿ÉÇгýµÄ½áÖ±³¦°©£¨CRC£©ÖеÄ×÷ÓÃÈÔȻûÓж¨ÂÛ¡£ÒÑ֪ͻ±äÇéÐεÄctDNA¼ì²â¾ßÓе¥¶À¾ÙÐÐÖ×Áö²âÐòMRD¼à²âµÄÓÅÊÆ£¬Õ¹ÏÖÁËÆä½«ÉúÎï±ê¼ÇÎïÖ¸µ¼µÄÖÎÁÆÕûºÏµ½Î§ÊÖÊõÆÚÖÎÁÆÖеÄDZÁ¦¡£
ÒªÁìѧ
GALAXY£¬Ò»Ïî´ó¹æÄ£µÄǰհÐÔÊÓ²ìÑо¿£¬¼à²âÁËÁÙ´²·ÖÆÚΪIIÖÁIVÒÔ¼°¸´·¢µÄ½áÖ±³¦°©»¼ÕßÊõºóctDNA MRD״̬£¨UMIN000039205£©¡£¶ÔÖ×Áö×éÖ¯ºÍ°©ÅÔ×éÖ¯DNA¾ÙÐÐÈ«ÍâÏÔ×Ó²âÐò£¨WES£©£¬ÒÔʶ±ðºÍ×·×Ù»¼ÕßÌØ¶¨µÄϵͳµ¥ºËÜÕËá±äÒ죨SNVs£©£¬²¢ÔÚÏà¹Ø»¼ÕßµÄѪ½¬Ñù±¾ÖоÙÐÐctDNA¼ì²â¡£Í¨¹ýSignatera¼ì²â£¬ÕâЩѡÔñÐÔÉúÎï±ê¼ÇÎ±»Ê¶±ðºÍÅжÏΪ¾ßÓÐOncoKBϵͳͻ±äÊý¾Ý¿â1-3µÄÖÎÁÆÆ·¼¶¡£
Ч¹û
ÔÚ2020Äê5ÔÂÖÁ2022Äê10ÔÂʱ´ú£¬¹²¹ÒºÅ»¼Õß4590Ãû£¬ÆäÖÐ2695Ãû»¼Õßδ±»ÕÐļÈëËæ»úÊÔÑéÇÒÓпÉÓõÄWESÊý¾Ý£¬ÄÉÈëÌìÖ°Îö¡£Ëùʶ±ðµÄÑ¡ÔñÐÔÉúÎï±ê¼ÇÎï°üÀ¨£ºÔÚ1369£¨50.8%£©»¼ÕßÖз¢Ã÷µÄRAS/BRAFÒ°ÉúÐÍ£¬ÔÚ256£¨10.3%£©»¼ÕßÖз¢Ã÷µÄ¸ßÖ×ÁöÍ»±ä¸ººÉ£¨TMB£©£¬ÔÚ236£¨9.5%£©»¼ÕßÖз¢Ã÷µÄ¸ß΢ÎÀÐDz»ÎȹÌÐÔ£¨MSI£©£¬ÔÚ176£¨6.5%£©»¼ÕßÖз¢Ã÷µÄBRAF V600E£¬ÔÚ61£¨2.3%£©»¼ÕßÖз¢Ã÷µÄKRAS G12C£¬ÔÚ47£¨1.7%£©»¼ÕßÖз¢Ã÷µÄERBB2À©Ôö£¬ÔÚ33£¨1.2%£©»¼ÕßÖз¢Ã÷µÄTP53 Y220C£¬ÔÚ1£¨0.04%£©»¼ÕßÖз¢Ã÷µÄNTRK1/2/3Èںϣ¬ÒÔ¼°ÔÚ1£¨0.04%£©»¼ÕßÖз¢Ã÷µÄRETÈںϡ£ÔÚÊõºó2µ½10ÖܵÄMRD´°¿ÚÄÚ£¬ctDNAµÄÑôÐÔÂÊ´ÓTMB¸ßºÍMSI¸ßµÄ5.1%ÖÁERBB2À©ÔöµÄ29.8%²»µÈ¡£ERBB2À©ÔöÊÇΨһÔÚMRD´°¿°¢ÚÄÚÓëctDNAЧ¹ûÕýÏà¹ØµÄÑ¡ÔñÐÔÉúÎï±ê¼ÇÎOR 2.20£©¡£DFSÏÔ׎ϲîµÄÑôÐÔctDNA MRDЧ¹ûÓëËùÓÐÑ¡ÔñÐÔÉúÎï±ê¼ÇÎïÏà¹Ø£¬HR¹æÄ£´ÓTP53 Y220CµÄ8.46µ½BRAF V600EµÄ5.53e+8¡£ÔÚMRD´°¿ÚÆÚ£¬MSI-HighµÄ»¼Õߣ¬225ÃûÒõÐÔctDNA»¼ÕßÖÐÖ»ÓÐ3ÈË·ºÆðÁ˸´·¢£¬¶øÔÚ¾ßÓÐÑôÐÔctDNAµÄ12ÈËÖеÄ5ÈË·ºÆðÁ˸´·¢¡£Í¨¹ýµ÷½âºó·¢Ã÷£¬ÔÚ²¡Àí·ÖÆÚΪIIºÍIIIµÄctDNAÑôÐÔ»¼ÕßÖУ¬¸¨Öú»¯ÁÆÎª»¼ÕßÌṩÁËÉúÑÄÒæ´¦¡£¼ì²â´Ó16¸ö±¸Ñ¡Í»±äÖУ¬Ñ¡Ôñ1¸ö»ò¶à¸öÍ»±ä¾ÙÐУ»¶øÕâ16¸öλµãÔÚ»¼Õ߸´·¢Ê±¶¼¿ÉÒÔ¼ì²âµ½¡£
½áÂÛ
±¾Ñо¿Í»³öÁËͨ¹ý¿ÉÑ¡ÔñÐÔÉúÎï±ê¼ÇÎ½«»ùÓÚctDNAµÄMRD×÷ΪһÖÖÕ¹Íû½áÖ±³¦°©¸´·¢¹¤¾ßµÄÖ÷ÒªÐÔ¡£Åú×¢MRDÇý¶¯µÄ°ÐÏòÖÎÁÆÕ½ÂÔÔÚ½áÖ±³¦°©ÖеļÛÖµ¡£
²Î¿¼ÎÄÏ×
²Î¿¼ÈªÔ´: Abstract #3609£¬Yoshiaki Nakamura£¬2024 ASCO Annual Meeting